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Symbol
Name
ID

Irf5
interferon regulatory factor 5
MGI:1350924

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Leukopenia

Pericarditis

Lymphadenopathy

Lupus nephritis

Nephritis

Abnormality of the immune system

Discoid lupus rash

Malar rash

Serositis

Decreased circulating complement C3 concentration

Decreased circulating complement C4 concentration

Anti-citrullinated protein antibody positivity

Antineutrophil antibody positivity

Perinuclear antineutrophil antibody positivity

Antinuclear antibody positivity

Anti-dsDNA antibody positivity

Anti-La/SS-B antibody positivity

Anti-Sm antibody positivity

Anti-U1 ribonucleoprotein antibody positivity

Antiphospholipid antibody positivity

Rheumatoid factor positive

Systemic lupus erythematosus

Disease(s) Associated with IRF5

rheumatoid arthritis

systemic lupus erythematosus

Mouse Phenotypes

immune system phenotype

decreased CD4-positive, alpha-beta memory T cell number

decreased leukocyte cell number

abnormal T-helper 1 physiology

decreased circulating interleukin-12b level

decreased circulating interleukin-6 level

decreased circulating tumor necrosis factor level

decreased interferon-alpha secretion

decreased interleukin-6 secretion

decreased tumor necrosis factor secretion

abnormal response to infection

decreased susceptibility to bacterial infection

Availability

Mouse Genotype

Irf5^{tm1e(EUCOMM)Wtsi}/Irf5^{tm1e(EUCOMM)Wtsi}

Irf5^tm1Ttg/Irf5^tm1Ttg

*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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